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  11. 2004: Drug Safety Accutane 7 Dec 2004. May 2000: Roche changes Accutane's package warning label to include possible side effects involving depression, rare suicidal thoughts,. Lawyers for Roche argued that the warning was adequate. It has been on the package insert for more than 20 years, and Accutane has been prescribed for more. accutane warning

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